A2 Chemistry Aspirin Coursework

The bond between the hydrogen and oxygen in the phenol group breaks where the oxygen takes both electrons and becomes stable.

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(Continue to Purification) The oxygen atom of the phenol group initiates a nucleophilic attack on a carbon in a carbonyl bond of the acetic anhydride.

As a result the oxygen of the phenol group becomes positively charged and the electrons forming the carbonyl bond in the acetic anhydride are pushed onto the oxygen of the bond and thus becomes negative.

Aspirin is a drug which is widely used today to deal with the symptoms of many minor illnesses ranging from general relief from aches and pain; muscle, tooth, headaches, and arthritis; to prevent blood clotting and reduce the risk of stroke and heart attack; lower fever and potentially prevent certain cancers.

Aspirin has a great history of development which could be considered to have begun in the 3000BC where it was recorded that remedies from the willow tree were the most useful for the treatment of many ailments.

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(Carman, 2008) The process of purification is relatively simple and is done by the process of hot and cold filtering.

Distilled water should be added to the impure ASA crystals.

Using the properties of ASA and the fact that it is soluble in hot water but virtually insoluble in cold water, any insoluble impurities can be removed by heating the mixture of water and ASA crystals to the point that the ASA crystals are just dissolved in the solution.

This hot solution should then be filtered into a clean beaker.

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