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Therefore new efforts have to be made in the field of translational oncology to improve the understanding, the diagnosis and the therapy of this disease.Apart from PDAC there are other pancreatic cancer types, which differ highly in patient outcome due to their tissue origin and genetic make up.Genetic analyses of patient samples have shown that the vast majority of those cancers display mutations in KRAS and the p16 locus.
Previous therapeutic approaches including surgical resection combined with adjuvant therapy or palliative chemoradiation have not achieved satisfactory results with respect to overall survival.Pancreatic cancer does not respond to a single-agent imatinib therapy.This disparity of outcomes merited further studies because interactions between these modalities depend on the imatinib-induced reduction of the tumor interstitial fluid pressure.For selected patients with borderline or unresectable disease, neoadjuvant therapy offers the potential for tumor downstaging, increasing the probability of a margin-negative resection and decreasing the occurrence of lymph node metastasis.Currently, there is no universally accepted approach for treating patients with pancreatic cancer in the neoadjuvant setting. These are the C595 monoclonal antibody that targets the MUC1 antigen and the PAI2 ligand that targets the u PA receptor.Of all carcinomas, pancreatic cancer has the highest mortality rate, with one- and five-year survival rates [...] Read more. It is the fourth leading cause of cancer-related death in Germany.Of all carcinomas, pancreatic cancer has the highest mortality rate, with one- and five-year survival rates of 25% and less than 5%, respectively, regardless of the stage at diagnosis.It is characterized by early metastasis and aggressive, infiltrative growth along the endothelium basement membrane and neurons.However, in recent years the crucial genetic changes leading to pancreatic cancer have been indentified.Please select whether you prefer to view the MDPI pages with a view tailored for mobile displays or to view the MDPI pages in the normal scrollable desktop version.This selection will be stored into your cookies and used automatically in next visits.